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《Journal of Shaoyang University(Natural Science Edition)》 2018-05
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The Role of Hepcidin in Iron Homeostasis and the Development of Targeted Hepcidin Drugs

ZHAO Jinying;LI Yanwei;School of Laboratory Medicine,Shaoyang University;The Key Laboratory of Molecular Biology Diagnosis,Shaoyang University;School of Clinical Medicine,Shaoyang University;  
Iron plays an important role in organisms,and iron absorption,storage and transport are precisely regulated.Hepcidin(Hepc),a peptide hormone produced by the liver,is the only recognized iron output protein so far.Hepcidin acts as a negative iron homeostasis regulator,which is able to inhibits the activity of ferroportin and thus inhibiting iron absorption in the intestine and iron release from iron storage organs. In addition to the liver,other organs also express a small amount of hepcidin. The expression of hepcidin is regulated by iron storage,erythropoietic activity,inflammation,hypoxia,endoplasmic reticulum stress and steroid hormones.Reduced expression of hepcidin would cause iron overload diseases,while elevated expression of hepcidin would lead to inflammatory or iron restricted anemia. At present,the development of drugs targeting hepcidin has become a focus issue in iron metabolism field.A series of hepcidin agonists or antagonists have entered clinical trials from the laboratory. This review mainly discusses the function of hepcidin in iron homeostasis and the progress of drugs development that targeting hepcidin.
【Fund】: 湖南省教育厅科研项目(16C1439)
【CateGory Index】: R91
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