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《Journal of Shenyang Pharmaceutical University》 1984-02
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STUDIES ON DOSAGE FORMS OF RIFAMPICIN AND THEIR BIOAVAILABILITY

Cai Yumin et al Department of Pharmacy  
The bioavailability of different dosage forms of rifampicin were studied in dogs,rabbits and healthy human volunteers using comparative experimental designs.It was found that the bioavailability of aliphatic base preparation of the drug was greater than that of its commonly-used preparations in the dosage form of capsules,tablets and suppositories,and that the toxic effect on liver was low.AUC~(0→) and MRT(Mean Residence Time)were calculated using the model-independent moment analysis method.The aliphatic base preparation containig 450mg of rifampicin could give the same drug level in plasma as the capsule with 600mg.It was,herefore,inferred that the amount of rifampicin administered in aliphatic base reparation can be decreased by 1/4—1/3 compared with that in capsule.
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