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《》 1984-02
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STUDIES ON GENETIC MANIPULATION OF STREPTOMYCES ERYTHREUS 1. Selection of the Revertant of A Zero producer of Streptomyces Erythreus

Xiong Zongqui Chen Guiqin Guo Rui Lu Taihua Department of Antibiotics  
The higher yielding strain was obtained through the reverse mutant of a zero producer of Streptomyces erythreus UV 80 by NTG treatment.To start with NTG treatment(1000μg/ml,lhr)zero mutants were prodruced and followed by NTG treatment again,a revertant showing a 8% higher activity was obtained.The revertant treated further by NTG(1000μg/ml,lhr),the resulted mutant yielded 25% more erthromycin than the original strain.The optimal dose of NTG mutagen was that of producing 90—94% death-rate.At the same time the correlation between the cultural characteristics and productivity of S. erythreus mutants was observed.
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【References】
Chinese Journal Full-text Database 1 Hits
1 Chen Gui-qin,Xiong Zong-qui,Chen Shu-bua Yuan Jie-li(Shenyang College of Pharmacy,Shenyang);A PRELIMINARY INVESTIGATION ON THE INDUCED MUTA-GENIC EFFECT OF NEAR ULTRAVILET LIGHT IN THE PRENSENCE OF 8-METHOXYPSORALEN ON S.ERYTHREUS[J];;1985-02
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