Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Practical Preventive Medicine》 2007-02
Add to Favorite Get Latest Update

Effect of Cordyceps Sinensis on Expression of p-Smad2/3 in Renal Interstitial of UUO Rats

ZHANG Hao,ZHANG Xian-ming,TANG Jing,et al.(Department of Nephrology,the Third Xiangya Hospital,Central South University,Changsha 410013,Hunan,China)  
Objective To observe the expression of p-Smad2/3 and TGF-β1 in renal interstitial of UUO rats after treatment with Cordyceps sinensis(Cs-4).Methods Fiftyfour male Sprague-Dawley rats were randomly divided into three groups: sham-operated group,UUO model group and Cs-4-treated group.Six rats of each group were sacrificed at the 7th,14th,and 21th days after operation.Histological changes were observed by HE,PAS and Masson staining.The expressions of p-Smad2/3,COL-IV and TGF-β1 protein were detected by immunohistochemistry,and the expression of TGF-β1 mRNA was observed by RT-PCR.Result The index of renal interstitial fibrosis,the expressions of p-Smad2/3,COL-IV and TGF-β1 protein in the renal interstitial,and the expression of TGF-β1 mRNA in renal tissue were decreased significantly in the Cs-4-treated group than those in the UUO model group.Conclusion In UUO rats,Cs-4 may postpone renal interstitial fibrosis by inhibiting the TGFβ-depended Smad signal pathway.
【Fund】: 湖南省自然科学基金(05JJ30059)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHAO De-an1a,YANG Da-sheng1a,BI Ling-yun1a,XU Hui-qin1b,ZHAO Ying2,CHEN Xin-de1a(1.a .Depart ment of Pediatrics ;b .Depart ment of Surgery ,the First Hospital Affiliatedto Xinxiang Medical College ,Weihui453100;2.Depart ment of Pharmacology ,Pharmacological College of Xinxiang Medical College , Xinxiang453003,China);Bailing Capsule in Preventing Epithelial -Mesenchymal Transitionin Rats with Tubulointerstitial Fibrosis[J];Journal of Applied Clinical Pediatrics;2005-09
2 ZHAO Yani, LI Jingzi, WANG Haiyan Division of Nephrology, the First Hospital of Peking University, Beijing 100034,China$$$$;Comparison of renoprotective effect between angiotensin Ⅱreceptor antagonist and angiotensin converting enzyme inhibitor on puromycin nephropathy and their possible mechanism[J];Chinese Journal of Multiple Organ Diseases in the Elderly;2002-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 GAN Lei,LI Lian,ZHAO Hong-wen,et al.(Department of Kidney,Southwest Hospital,the Third Military Medical University,Chongqing 400038,China);Study of the renal fibrosis progression of 5/6 nephrectomized rats transfected by transgene of antisense vascular smooth muscle alpha actin[J];Chongqing Medicine;2008-08
2 LIU Lun-zhi~1,NING Jian-ping~2,WANG Lian-kai,et al.(Department of Nephrology,Affiliated Hospital of Hubei Institute for Nationalities,Enshi 445000,China);Effects of Losartan on Expression of Transforming Growth Factor-β_1 and p38 Mitogen-activeted Protein Kinase in Renal Tubular Epithelial Cells of Diabetic Rat[J];Journal of Hubei Institute for Nationalities(Medical Edition);2006-01
3 LIU Lun-zhi,NING Jian-ping(Department of Nephrology,Affiliated Hospital of Hubei Institute for Nationalities,Enshi 445000,China);Effects of Losartan on Renal Tubular Epithelial Cells Transdifferentiation in Streptozotocin-induced Diabetic Rats[J];Journal of Hubei Institute for Nationalities(Medical Edition);2006-02
4 Yi Li,Shu Guiyang,Chen Youming,et al.Fujian Provincial Hospital,Fuzhou 350001,China;The expression and significance of transforming growth factor-β_1 in rats with renal tubulointerstitial fibrosis[J];Fujian Medical Journal;2007-04
5 XIA Yu-min JIANG Shan XU Shi-zheng DING Guo-hua YANG Hong-xia Depart- ment of Dermatology,Renmin Hospital of Wuhan University,Hubei 430060,China;Effect of emodin on phenotype transformation of mesangial cells induced by IgG subtype of anti-dsD-NA antibodies[J];Chinese Journal of Rheumatology;2007-05
6 Yan Run.Division of Nephrology,The affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China;The expression and significance of PDGF-B in rats with renal interstitial fibrosis[J];Guizhou Medical Journal;2009-06
7 WANG Yin1, TONG Jun-rong1, LUO Zheng-mao1, HE Feng1, MA Li2 1Deparment of Nephrology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China; 2Institute of Molecular Immunology, School of Biotechnology, Southern Medical University, Guangzhou 510515, China;Effects of urokinase on renal interstitial fibrosis and transforming growth factor-β1 in the kidney of rats with chronic cyclosporine A nephropathy[J];Journal of Southern Medical University;2009-12
8 WAN Qing-song,XIE Hong-ping,OU Ji-hong (Department of Nephropathy,The First Affiliated Hospital of Nanhua University,Hengyang 421001,China);Protection of Type 2 Diabetic Nephropathy Therapied by Spironolactone[J];Journal of Hunan Environment-Biological Polytechnic;2008-04
9 NING Jian-ping1, YANG Shen1, NING Chen2,ZENG Ying-hui1, LIU Lun-zhi1, LIU Jun1(1.Department of Nephrology, Xiangya Hospital, Central South University, Changsha 41000;2.Xiangya School of Medicine, Central South University, Changsha 410078, China);Effect of integrin-linked kinase on renal tubular epithelial cell transdifferentiation in diabetic rats[J];Journal of Central South University(Medical Sciences);2007-01
10 YU Qing1,2),LIU Zhangsuo1),LI Hong1) 1) Department of Nephrology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 4500522) Department of Nephrology,the First Affiliated Hospital, Henan College of TCM,Zhengzhou 450000;Protective effects of spironolactone on chronic cyclosporine A nephrotoxicity in rats[J];Journal of Zhengzhou University(Medical Sciences);2007-06
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 Research lnstitute of Nephrology,Jinling Hospital,Nanjing,210002 Zheng Feng,Liang Lan-Qing,Li Lei-Shi,et al;Cordyceps sinensis stimulates proliferation of renal tubular cell and protects against gentamicin nephrotoxicity in rat[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1995-02
2 LI Zilong, ZHOU Xijing, REN Qing. et al. (Department of Nephrology, The First .4ffiliated Hospital, China Medical University, Shenyang 110001, China);Effect of Cordyceps sinensis on distribution of anionic sites on glomerular basement membrane in rat passive Heymann nephritis[J];Chinese Journal of Nephrology;2001-03
3 CHU Fei, ZOU Wan-zhong, SUN Suo-zhu, HAN Zhi-hui, WANG Sheng-lan. Department of Pathology, Health Science Centre of Peking University, Beijing 100083, China;Study of renal tubular epithelial cells transformations in rat tubulointerstitial fibrosis[J];Chinese Journal of Nephrology;2003-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved