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《Practical Preventive Medicine》 2007-02
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Effects of Atorvastatin on Expression of ICAM-1 After Cerebral Ischemia/reperfusion Injury in Rats

GU Wen-ping,XIAO Hui,HUANG Lei,et al.(Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008,Hunan,China)  
Objective To investigate the impact of atorvastatin on the expression of ICAM-1 in the rat's brain tissue after ischemia/ reperfusion(I/R) injury. Methods Rats were subjected to cerebral I/ R injury through the occlusion of the middle cerebral artery.Neurological deficits were determined according to the Longa′s score.The expression of ICAM-1 was detected by immuno-histochemical technique.The effusion of PMNLs in brain tissue was evaluated by HE staining.Results The expression of ICAM-1 in the ischemic territory increased after cerebral ischemia(P0.01), and peaked at 24h after ischemia.Atorvastatin treatment decreased the expression of ICAM-1(P0.05),inhibited the effusion of PMNLs(P0.05),and improved the Longa′s score(P0.05).Conclusion Atorvastatin-calcium protects the brain tissue against ischemia reperfusion injury through inhibiting the expression of ICAM-1 after focal cerebral ischemia reperfusion in rats.
【Fund】: 教外司留学回国基金(教外司留[2006]331号);; 湖南省自然科学基金(02JJY3028);; 湖南省卫生厅课题(B2005023)
【CateGory Index】: R743.3
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HAN Xue mei 1,XIONG Wen ji 2,HU Guo zhong 3 (1. Department of Neurology, China Japan Union Hospital,Jilin University,Changchun 130031,China; 2. Department of Cadre Ward, First Hospital,Jilin University,Changchun 130021,China; 3. Department of Prevention and Health Pharmacy,China Japan Union Hospital,Changchun 130021,China);Effects of Ginaton on expressions of Fas and Bcl-2 protein in rats with cerebral ischemia reperfusion injury[J];Journal of Jilin University of (Medicine Edition);2004-03
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6 HAN Ying, LIU Nan, CHEN Rong-Hua, ZHENG An, and HUANG Hua-Pin(Department of Neurology, Union Hospital, Fujian Medical University, Fuzhou 350001, China);The Changes of Interleukin-8 Content after Cerebral Ischemia-Reperfusion Injury in Rats[J];Chinese Journal of Arterial Lerosis;2005-02
7 DONG Shao-Hong,WEN Jun-Min,LUO Lin-Jie,CHEN Ke-Qi,LIANG Xin-Jian,LI Yi-Fu,LIU Hua-Dong,CHEN Huan-Zhan,and HUANG Zhi-Xin (Department of Cardiology,the Second Affiliated Hospital of Medical College of Jinan University,Shenzhen 518026,China);The Effect of 40mg/d Atorvastatin on Patients with Acute Coronary Syndromes[J];Chinese Journal of Arteriosclerosis;2006-07
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9 GU Wen-Ping,XIAO Hui,LI Wei,LI Xiao-Jun,LIU Fu-Zhong,SONG Xiao-Ming,and YANG Qi-Dong(Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008,China);Effects of Atorvastatin on Inflammatory Response of Cerebral Ischemia—Reperfusion Injury in Rats[J];Chinese Journal of Arteriosclerosis;2007-01
10 ZHANG Shi-Ming, SUN Xue-Bo Department of Neurosurgery, Affiliated First Hospital. Suzliou University, Suzhou, 215006, China;Research of P-,L-selectin Expression After Ischemia-reperfusion in Rat[J];Chinese Journal of Clinical Neurosciences;2003-04
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