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《Practical Preventive Medicine》 2007-02
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Effect of Maxin Shigan Decoction and its Alteration on Mice T-cell Subpopulation Exposured to Influenza Virus A

ZHAO Wu-neng,LU Fang-guo,ZHANG Wei,et al.(1.Traditional Chinese Medicine University of Hunan,Changsha 410007,Hunan,China; 2.Hunan Agricultural University,Changsha 410200,Hunan,China)  
Objective To investigate the effect of maxin shigan decoction(MSD) and its alteration on mice T-cell subpopulation exposed to influenza virus A.Methods The models were established by inoculating with the influenza virus A fitted to lung via mice nose in mice and then divided into 10 times of MSD,5 times of MSD,infected model and normal control groups.The normal salt solution was filled up in the control and infected groups and the drug MSD in relevant concentration in the other 2 groups,1 time per day,each time with 0.4ml,and lasted for 8 days. The water or drug was forbidden for 8 hours after the last time of filling up,and then,the percentage of T-cell subpopulation was measured from the experimental animals.Results The percentages of CD3+ and CD4+T-cell subpopulation and the ratio of CD4+/CD8+ in the 10 times MSD group were significantly higher than those in the infected model group(P0.05) while the percentage of CD8+T-cell subpopulation was significantly lower than that of the infected model group(P0.05).The percentages of CD8+T-cell subpopulation in both 10 and 5 times of MSD groups were significantly lower than those of the infected model group(P0.05).Conclusion MSD in the largest dosage(10 times of clinical dose) and supplemented MSD in the largest dosage(5 times of clinical dose) can obviously regulate the percentage of T-cell subpopulation in mice exposed to influenza virus A.
【Fund】: 湖南省自然科学基金资助项目(06JJ20055)
【CateGory Index】: R285.5
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【Co-references】
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