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《Practical Preventive Medicine》 2007-02
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Relationship Between PPARr2 Gene Pro12Ala Polymorphism and Cerebral Infarction

HUANG Lei,GU Wen-ping,LI Wei,et al.(Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008,Hunan,China)  
Objective To investigate the relationship between peroxisome proliferator activated receptorγ2(PPARr2) gene Pro12Ala polymorphism and cerebral infarction in Changsha population.Methods Pro12Ala of PPARr2 in 190 patients with cerebral infarction and 200 non-cerebral infarction control subjects were analyzed by PCR-RFLP and electrophoresis,and their data of TG,TC,HDL,LDL,fasting glucose,blood pressure,BMI and IMT were collected and reviewed.Results Allele frequencies of Pro12Ala mutation of PPARγ2 Pro12Ala polymophism in the cerebral infarction group were PP 0.900 and PA 0.095,and PP 0.884 and PA 0.116 in the control group.No statistical significiant difference was found in distribution of genotype between these two groups (P0.05).Distribution of frequencies of each genotype of Pro12Ala variant of PPAR-γ2 was not significantly associated with BMI,fasting glucose,blood pressure,and lipid profiles.In the cerebral infarction group,subjects with PPARγ2 allele had higher carotid IMT(P0.05).Conclusion The Pro12Ala mutation in PPARγ2 is not associated with cerebral infarction;but the variant of PPAR-γ2 might promote the increase of carotid IMT in patients suffering from cerebral infarction.
【Fund】: 2006中南大学大学生教育计划项目;; 湖南省自然科学基金(02JJY3028);; 教外司留学回国基金(教外司留[2006]331号;; 湖南省卫生厅课题(B2005023)
【CateGory Index】: R743.3
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