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《Practical Preventive Medicine》 2007-02
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HLA-A Genetic Polymorphism in a Chinese Mongolian Population

WANG Fan,TIAN Wei,LI Li-xin,et al.(Department of Immunology,School of Basic Medical Sciences,Central South University,Changsha 410078,Hunan,China)  
Objective The genes encoding human leucocyte antigen are highly polymorphic,however,previous studies regarding the HLA distribution in Chinese populations have mainly focused on Chinese Han populations residing at various geographic regions.Our study was designed to explore the HLA-A genetic polymorphism of Chinese Mongolian population at DNA level. Methods Eighty-three unrelated healthy individuals of Mongol,recruited from Inner Mongolia,were typed for HLA-A locus by using amplification refractory mutation system-polymerase chain reaction(ARMS/PCR) technique. Results Eleven HLA-A alleles(groups) were found,the most frequent alleles were HLA-A*02,A*11,and A*24,with gene frequencies of 0.2886,0.1713,and 0.1569 respectively.In this sample panel,HLA-A19 broad specificity was composed of HLA-A*29,A*30,A*31,A*32,and A*33 splits,which were summed to a frequency of 0.2368.In addition,HLA-A*01 was a relatively common allele with gene frequency of 0.08823. Conclusion Our study provides the data of HLA-A genetic polymorphism of a Chinese Mongolian population at DNA level.
【Fund】: 中南大学留学归国人员科研启动基金资助
【CateGory Index】: R394
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【Citations】
Chinese Journal Full-text Database 5 Hits
1 TIAN Wei*, LI Li-xin, LUO Qi-zhi, MA Hai-jun, YU Ping, YAN Mei-yu, GUO Shi-shi, CAO Ya. *Department of Immunology, Cancer Research Institute, Xiang-Ya School of Medicine, Central South University, Changsha 410078, China;MICA-STR genetic polymorphism in a southern Chinese population[J];Chinese Journal of Microbiology and Immunology;2005-06
2 ZOU Yizhou, GOU Shishi. Research Laboratory of Immunology, Hunan Medical University, Changsha 410078;Study of polymorphism HLA A locus allele using ARMS/ PCR SSP on Hunan Hans[J];Chinese Journal of Microbiology and Immunology;1999-04
3 ZHANG Hong-bo, LAI Jiang-hua, LI Sheng-bin. (The Key Laboratory of National Ministry of Health for Forensic Sciences, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi' an,Shaanxi,710061 P.R.China);Analysis on HLA haplotypes of loci HLA-A, -B, and -DRB1 in northwest Chinese Han population[J];Chinese Journal of Medical Genetics;2005-04
4 HAN Shi-xin1, SHANG Ying-bin2,LI Jiu-hong2,GENG Long2,ZHAI Ning2,CAO Kai2, SONG Fang-ji2. 1(Department of Dermatology, the First Hospital of Dalian Medical University, Dalian,Liaoning, 116011 P. R. China); 2(Department of Dermatology, the First Hospital of China Medical University, Shenyang,Liaoning, 110001 P. R. China);High resolution DNA typing for HLA-A, B, Cw genes by polymerase chain reaction-sequence specific oligonucleotide probes method in the Shenyang Han population[J];Chinese Journal of Medical Genetics;2005-06
5 Zhang Xiuwu Guo Shishi (Research Laboratory of Immunology,Hunan Medical University,Changsha 410078);Analysis of DNA polymorphism of HLA—DQ locus with PCR/SS0 in Hunan Hans[J];Chinese Journal of Immunology;1993-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 JIN Da-qing, ZHENG Xiu-fen (Chinese People's Public Security University , Beijing 100038);HLA gene polymorphism and forensic medicine[J];Journal of Forensic Medicine;2003-01
2 YUAN Xin1),GAO Xu2),SHE Hongchun3),ZHU Aizhi1)1)Department of Blood Transfusion,the Fifth Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Blood Transfusion,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014 3)Department of Experiment,School of Medical Sciences,Zhengzhou Railway Vocational Technology College,Zhengzhou 450052;Analyse on HLA-A,B,and DRB1 gene polymorphism of people with HLA-B_(27) positive among Han population in Henan area[J];Journal of Zhengzhou University(Medical Sciences);2007-04
3 Hong Kunxue,Chu Jiayou,Wei Candong,Qian Yaping,Xu Shaobin,Yang Zhaoqing (Institute of Medical Biology,Chinese Academy of Medical Sciences,Kunming 650107);FAST DNA GENOTYPING OF HLA DR4 IN LAHU CHINESE[J];IMMUNOLOGICAL JOURNAL;1999-04
4 CAO Jian ping1,LI Ping2, LIU Ya ge1, PU Fei fei1, MONG Lu lu1, AN Tian yi11Department of Experimental Medicine, Chinese PLA General Hospital of Shenyang Military Command Area, Shenyang 110015, Liaoning Province, China 2Clinical College of Chinese Med;DR4-DRB1 allele typing in donors and recipients of kidney-transplantation[J];JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY;2000-01
5 GONG Zhe, LIN Zhi-xiong, HU Sheng-ping (Cancer Hospital, Shantou University Medical College, Shantou 515031, China);Correlation Between HLA and Nasopharyngeal Carcinoma among Southern Chinese Population[J];Journal of Oncology;2008-10
6 WANG Zhi-peng, GUO Shi-shi, YU Ping;Correlative study on HLA-DR allelic polymorphisms and nasopharyngeal carcinoma in the Han nationality in Hunan province[J];Chinese Journal of Pathophysiology;2005-05
7 Guo Ailin Sui Yanfang Zhang Lihong et al Department of Pathology,Fouth Military Medical University,Xi'an;Reconstituted Heat Shock Protein-Peptide Complex in Vitro and Induction of Peptide-specific Cytotoxic T Lymphocyte Response of Hepatocellular Carcinoma[J];Chinese Journal of Clinical Oncology;2001-10
8 Pan Xinghua,Lu Jianrong, Liu Jie. et al 'Institute of Genetics, Fudan University, Shanghai 200433;STUDIES ON THE GENETIC POLYMORPHISM OF HLA-DQA1 LOCUS IN TWO GROUPS OF CHINESE HANS AND COMPREHENSIVE ANALYSIS OF DQA1 GENE FREQUENCIES IN 15 RELATED GROUPS[J];Chinese Journal of Microbiology and Immunology;1995-04
9 TIAN Wei, LI Lixin, ZHOU Jinfeng, GUO Shishi. Immunology Research Laboratory, Hunan Medical University, Changsha 410078,P. R. China;Genetic polymorphism of HLA-Cw locus in a southern Chinese Han population analyzed by ARMS/PCR genotyping[J];Chinese Journal of Microbiology and Immunology;2002-01
10 ZhangXiuwu*,LuJie,ZhangZhijiong,etal.*DepartmentofMolecularPharmacology,HunanMedicalUni-versity,Changsha410078;IdentificationofthehomozygousandheterozygousblankalelesofDPB1withPCR┐SSCP[J];CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY;1996-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 TIAN Wei, LI Lixin, ZHOU Jinfeng, GUO Shishi. Immunology Research Laboratory, Hunan Medical University, Changsha 410078,P. R. China;Genetic polymorphism of HLA-Cw locus in a southern Chinese Han population analyzed by ARMS/PCR genotyping[J];Chinese Journal of Microbiology and Immunology;2002-01
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