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《Practical Preventive Medicine》 2007-02
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Side Effects on Blood System in IFNa-2b Against Hepatitis C

JIANG Jian1,2,LI Deng-qing1,LI Juan2,et al.(1.Department of Medical Laboratory,Xiangya Medical College of Central South University,Changsha 410013,Hunan;2.Futian District Hospital of Traditional Chinese Medicine,Shenzhen 518034,Guangdong)  
Objective To investigate the blood changes in chronic hepatitis C patients cured with IFNa-2b.MethodsAccording to the dosage of IFNa2b,42 patients were assigned into two groups,one group was treated with 3MU,and another group with 5MU.SYSMEX KX-21 was used to detect the patient's white blood cell,hemoglobin and platelet before and after taking the IFNa-2b therapy. ResultBefore treating with IFNa-2b,the levels of WBC,HGB and PLT in these two groups showed no statistical difference,while after the treatment,white blood cell and platelet stepped down differently in a dose-dependant manner.Conclusion The IFNa-2b therapy shows adverse effects on blood system in a dose-dependant manner,and the 3MU regimen might be the first choice in the treatment.
【Fund】: 深圳市福田区科技局(FT200627)
【CateGory Index】: R512.6
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 MA Li-na, CHEN Xin-yue, CHEN Jie, SHEN Cheng-li, WANG Jun-tao. Beijing Youan Hospial,Capialtal University of Medical Sciences, Beijing 100054, China;Efficacy, influencing factors and safety of PEG-INF alpha-2a (PEG-INF-2a) in the treatment of chronic hepatitis C:analysis of 89 patients[J];Chinese Journal of Experimental and Clinical Virology;2006-02
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 ZHOU Dong-sheng,XU Ru,XIAN Yong-chao.(Affiliated Hospital of Guilin Medical College,Guilin 541001,Guangxi,P.R.China);Clinical observation on efficacy of varius antibiotics in treatment of chronic HCV patients[J];China Tropical Medicine;2008-07
2 QU Fan,LI Hong-ri(Department of Pediatrics,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China);Effects of Recombinant Human Erythropoietin on Immune Function of Chemotherapy Mice[J];Journal of Applied Clinical Pediatrics;2006-21
3 Wang Yu-bin,Chen Wen-jun,Zheng Wei-e,et al;Randomized Comparison the Clinical Trial of High or Common-dose Erythromycin Treatment in Anemic Patients with Cancer[J];Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine;2007-02
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Li Li,Jun Cheng,Fan Li,Jian-Jun Wang,Jian Zhang,Qin Wu,Ping Han,Guo-Feng Chen,Dong Ji,Ke Li,Gene Therapy Research Center,Instituteof Infectious Diseases,The 302 Hospital of PLA,Beijing 100039,China;Clinical and pathological characteris-tics of steatohepatitis in patients with chronic hepatitis C virus infection[J];World Chinese Journal of Digestology;2002-09
2 XU Dao zhen, XIE Yao, LU Zhi meng, et al. Department of Infectious Diseases, Beijing Ditan Hospital, Beijing 100011, China;Randomized,Open-label and active controlled study of PEG-IFNα-2a in the treatment of chronic hepatitis C in China[J];Chinese Journal of Infectious Diseases;2004-04
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