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《Practical Preventive Medicine》 2007-02
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Effect of Jianwei Yuyang Granule on Expression of TGF-β1mRNA in Gastric Mucosa in Patients With Gastric Ulcer

LIN Yuan,ZHOU Yong-jie,LIAO Shu-sheng,et al.(Institute of Combined Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha 410008,Hunan)  
Objective: To explore the effects and its mechanism of Jianwei Yuyang Granule(JYG) on gastric mucosa of gastric ulcer patients.Methods Fifty-six cases of peptic ulcer patients with stagnation of liver-qi and deficiency of spleen were ran-domly assigned into two groups,a26-case treatment group received JYG and a30-case control group received famotidine and ulcerlmin standard therapy.In addition,patients those who were Hp positive received amoxicillin and metronidazole as well,and4-week as one treatment course.All cases received gastroendoscopic biospy and the expression of TGF-β1mRNA was measured with RT-PCR before and after treatment.Results The TGF-β1mRNA which raised significantly after treatment was expressed weakly in normal gastric mucosa and increased moderately in both groups before treatment.The expression level of TGF-β1mRNA was different between JYG treatment group and the control group(P0.01).Con-clusion JYG improves and accelerates the ulcer healing by increasing the expression of TGF-β1.
【Fund】: 湖南省科技厅科技计划重点项目(02SSY1005-4)
【CateGory Index】: R259
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