Distinctive Sequence Characteristics of Pre-core Genome of Hepatitis B Virus e Antigen in Different Serotypes and Genotypes
ZHANG Min,XIN Shao-jie,HE Jing,et al.(The Postgraduate Medical College of PLA, Beijing 100853,China)
Objective To investigate the characteristics of pre-core genome of hepatitis B virus(HBV) e antigen in different serotypes and genotypes.Method Twelve serotypes and 30 genotypes of HBV complete sequences from Genbank were selected for this study.Sequence comparison of HBV pre-core genome was conducted and blast software was employed to find sequence variations.Results Six-nucleotide insertion was found in Adw serotype HBV genome sequences and 1 nucleotide insertion was found in genotype B HBV nucleotide sequences.Nucleotide 1896 variation (T-A) appeared in serotype Adr and Adw genome,as well as genotype A,B,C,D and G sequences.Nucleotide 1858 variation appeared in serotype Adw,as well as genotype A,F and H genome sequences.Conclusion HBV Pre-core genome variation of e antigen consists of two types: insertion mutation and point mutation,which manifests different characteristics in different serotypes and genotypes,and may have different clinical significance.
【CateGory Index】： R373.2