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《Practical Preventive Medicine》 2007-02
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Mechanism of Anti-atherogenesis Effect of Soluble Tannins From Fructus Phyllanthi

GUO Ai-xiu,HUANG Xing-Guo,TANG Xiang-yun(Hunan Institute of Environmental & Biological Technology,Hengyang 421001,Hunan)  
Objective To clarify the mechanism of antiatherogenic effects of Phyllanthus emblica L.,which is widely used in treatment of atherosclerosis-related diseases and associated with ox-LDL by the soluble tannin,Phy-13(beta-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose),and its analogue Phy-16(1,6-di-O-galloyl-beta-d-glucose).Methods Human arteria umbilical endothelial cells,ECV-304,were incubated with ox-LDL(50 mg/l),treated with corilagin or Dgg16 at different doses,and then incubated with monocytes.Malondialdehyde(MDA) in the culture media was determined and the number of monocytes adhering to ECV-304 cells was counted cytometrically.The rat vascular smooth muscular cells(VSMC) were incubated in media with or without ox-LDL(50 mg/l),and with Phy-13 or Phy-16 at different doses too, and the proliferation of them was assayed by MTT method.Results Both Phy-13 and Phy-16 were able to reduce MDA content,prevented ECV-304 cells from being adhered by the monocytes,and inhibited VSMC proliferation that induced by ox-LDL.Conclusion These two compounds are effective in inhibiting the progress of atherosclerosis by alleviating oxidation injury or by inhibiting ox-LDL-induced VSMC proliferation,which may be the promising mechanisms for treating atherosclerosis.
【CateGory Index】: R285
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