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《Practical Preventive Medicine》 2007-02
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Mechanism of Anti-atherogenesis Effect of Soluble Tannins From Fructus Phyllanthi

GUO Ai-xiu,HUANG Xing-Guo,TANG Xiang-yun(Hunan Institute of Environmental & Biological Technology,Hengyang 421001,Hunan)  
Objective To clarify the mechanism of antiatherogenic effects of Phyllanthus emblica L.,which is widely used in treatment of atherosclerosis-related diseases and associated with ox-LDL by the soluble tannin,Phy-13(beta-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose),and its analogue Phy-16(1,6-di-O-galloyl-beta-d-glucose).Methods Human arteria umbilical endothelial cells,ECV-304,were incubated with ox-LDL(50 mg/l),treated with corilagin or Dgg16 at different doses,and then incubated with monocytes.Malondialdehyde(MDA) in the culture media was determined and the number of monocytes adhering to ECV-304 cells was counted cytometrically.The rat vascular smooth muscular cells(VSMC) were incubated in media with or without ox-LDL(50 mg/l),and with Phy-13 or Phy-16 at different doses too, and the proliferation of them was assayed by MTT method.Results Both Phy-13 and Phy-16 were able to reduce MDA content,prevented ECV-304 cells from being adhered by the monocytes,and inhibited VSMC proliferation that induced by ox-LDL.Conclusion These two compounds are effective in inhibiting the progress of atherosclerosis by alleviating oxidation injury or by inhibiting ox-LDL-induced VSMC proliferation,which may be the promising mechanisms for treating atherosclerosis.
【CateGory Index】: R285
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China Proceedings of conference Full-text Database 1 Hits
1 Wu Xiaodan1,Jin Zhexiong 2(1.Northeast Forestry University,Harbin150040;2.Harbin University of Commerce,Harbin 150076);Progress of Research on Tannins from Traditional Chinese Medicine[A];[C];2008
Chinese Journal Full-text Database 1 Hits
1 Tu Yong-sheng1,Wang Hong-yan21Department of Physiology,2Department of Pathology,Guangzhou Medical College,Guangzhou 510182,Guangdong Province,China;Oxidized low-density lipoprotein induces vascular smooth muscle cells proliferation and cyclin D1 expression in rats[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-15
Chinese Journal Full-text Database 10 Hits
1 YAO Si-yu, ZHAO Peng, LIU Rong-zhen, et al. (Guangxi Autonomus Region Center for Disease Control and Preventiorn, Nanning 530021, Guangxi, P. R.China );Experimental study on the Tannin’s effect in reducing blood lipid in animals[J];China Tropical Medicine;2004-06
2 Cai Yingqing1,2 Lai Zhongxiong1 Xu Wanzhen2 Chen Yiting3 Cai Jianxiu2 Pan Dongming (1 Institute of Horticultural Biotechnology, Fujian Agriculture and Forestry University Fuzhou Fujian 350002; 2 Biology Department, Quanzhou Normal University Quanzhou Fujian 362000; 3 Institute of Fruits, Fujian Academy of Agricultural Sciences Fuzhou Fujian 350013 China);Analysis of Total Flavonoids in Different Organs of Phyllanthus emblica L.[J];Chinese Journal of Tropical Crops;2005-01
3 Cai Yingqing1,2 Lai Zhongxiong1 Shen Jinshan2 Chen Yiting3 Li Guoqing2 Lin Yuling1 Zheng Wenlu41 Institute of Horticultural Biotechnology, Fujian Agriculture and Forestry University Fuzhou Fujian 350002 2 Biology Department, Quanzhou Normal University Quanzhou Fujian 362000 3 Institute of Pomology, Fujian Academy of Agricultural Sciences Fuzhou Fujian 350013 4 Xitianwei Town of Licheng District Putian Fujian 351131 China;Detection of Superoxide Dismutase Activities in Different Organsin Phyllanthus emblica L.[J];Chinese Journal of Tropical Crops;2006-04
4 MEI Wen-li1,2, DAI Hao-fu1*, WU Da-gang2 (1. State Key Laboratory of Tropical Crops Biotechnology, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China; 2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming 650204, China);Phenolic Constituents from Ailanthus fordii Nooteboom[J];Journal of Tropical and Subtropical Botany;2006-05
5 Xie Daogang Song Guangzhi Liu Jing Sichuan Provincial Institute of Traditional Chinese Medicines, Chengdu 610031;Tannin Measurement and Associated Methodological Verification (Chinese Pharmacopoeia 2005)[J];;2006-06
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7 ;石榴皮单宁类化合物的提取研究[J];Science and Technology of Food Industry;2007-01
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9 LIU Limei, LI Bao-wen, WANG Lvya. Department of Neurology, the 2nd Affiliated Hospital of Dalian Medical University, Liaoning 116023, China;Effect of Emblica officinalis on Formation of Atherosclerotic Plaque in Hypercholesterolemia Rabbits[J];Applied Journal of General Practice;2005-02
10 LI Ning1,LI Xian1,FENG Zhi-guo2,MASAYUKI Yoshikawa3(1.School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China;2.Tianjin Tanabe Seiyaku Co.Ltd.,Tianjin,300385,China;3.Kyoto Pharmaceutical University.Kyoto,Japan);Chemical constituents from Canavalia gladiata[J];Journal of Shenyang Pharmaceutical University;2007-11
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