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《Practical Preventive Medicine》 2007-02
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Effect of Lovastatin on Plasma Soluble Intercellular Adhesion Molecule-1 and Pselectin in Patients With Coronary Artery Disease

CHEN Bai-yu,LI Xi-qin,KUANG Xiao-qin,et al.(Affiliated Hospital of Xiangnan University,Chenzhou 423000,Hunan)  
Objective To observe the effect of lovastatin on plasma levels of soluble intercellular adhesion molecule-1 and soluble P-selectin in patients with coronary artery disease and to investigate its action on non-lipid anti-inflammation mechanisms.Method Ninety-nine patients with coronary artery disease(CHD) were randomly assigned into two groups: a control group with basic treatment and a treatment group with basic treatment plus lovastatin.All patients were treated for eight weeks.Before and after the treatment,blood lipids were measured by auto-chemistry analysis detector.Plasma soluble intercellular adhesion molecule-1 and soluble P-selectin were measured by enzyme-linked immunosorbent assay(ELISA).Follow-up was conducted for three months.Results After the treatment,the serum levels of cholesterol(TC),low dense lipoprotein cholesterol(LDL-C),triglyceride(TG) and apolipoprotein(ApoB) in treatment group declined significantly;serum high dense lipoprotein cholesterol(HDL-C) and apolipoprotein(ApoA) increased significantly;while plasma soluble intercellular adhesion molecule-1 and P-selectin decreased significantly(P0.05).There showed no difference between before and after treatment in control group(P0.05).Coronary events occurred in 2 cases of the treatment group(4%) and 7 cases of the control group(14.3%),and the incidence in treatment group was significantly lower than that of control group.Conclusion The results suggest that lovastatin has non-lipid anti-inflammatory effect on inhibiting plasma soluble intercellular adhesion molecule-1 and P-selectin,which can reduce coronary events in patients with CHD.
【CateGory Index】: R541.4
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1 Cao Long,Shen Weilin,Wang Mengdi(The People's Hospital of Jinhu County,Jinghu 211600,Jiangsu,China);Effect of Lovastatin on arteriosclerosis plaque of carotid artery[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2009-10
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