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《Practical Preventive Medicine》 2007-02
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Expression and Significance of IL-18 in Chronic Congestive Heart Failure

LIU Zhao-yun,JIANG De-qian,TANG Xiao-hong,et al.(Department of Cardiology,Second Xiangya Hospital of Central South University,Changsha 410011,Hunan)  
Objective To explore the relationship between IL-18 expression and chronic congestive heart failure(CHF).Methods Plasma level of IL-18 was measured by enzyme-linked immunososrbent assay(ELISA) in 30 patients with chronic congestive heart failure and 32 healthy controls.ResultsThe level of IL-18 was significantly higher in patients with CHF(375.6±169.3)ng/L than in the healthy controls(227.6±86.5)ng/L,P0.01. ConclusionThe elevated level of IL-18 in patients with CHF suggests that the inflammatory cytokine IL-18 might play an important role in CHF.
【CateGory Index】: R541.6
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