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《Practical Preventive Medicine》 2007-02
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Effect of Rare Earth Element Lanthanum Subchronic Exposure on Peripheral Blood General Examination Index in Rat

WANG Tian-cheng,HE Xiao,ZHANG Zhi-yong,et al(Department of Clinical Laboratory,3rd Hospital of Peking University,Beijing 100083,China)  
Objective To explore the effect of lanthanum subchronic exposure on peripheral blood cells index in rat models.Methods The Wistar rats were treated with oral exposure dose 0.1,2 and 40 mg/kg of lanthanum chloride(LaCl3) respectively,after 90 days the rats were sacrificed and the blood was collected for blood general index examination.Results There showed no significant difference among the control group and 3 dose-groups of LaCl3 exposed rats on WBC,lymphocytes(LYM) and LYM%,RBC,HGB,Hct,MCV,MCH,MCHC,RDW-SD and RDW-CV,PLT,PDW and MPV indices(P0.05).Conclusion The results indicate the lanthanum subchronic exposure shows no significant effect on blood general examination index in rat.
【CateGory Index】: R114
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