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《Reproduction and Contraception》 2003-06
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Relationship between Hysteroscopic Findings and Leukaemia Inhibitory Factor in Mid-secretary Endometrium

Lu FANG, Yu-bao WANG, Zhong-mei LI, Xiao-yun WU, Zuan-chong FENG (Shanghai Institute of Planned Parenthood Research, Shanghai, 200032)  
Objective:To explore the potencial relationship between hysteroscopic findings,and the concentrationa of leukaemia inhibitory factor (LIF) in uterine flushing as well as the expression of LIF in the endometrium. Methods: Hysteroscopy was carried out among 64 infertile female patients and uterine flushing was collected for LIF assay in the mid-secretory phase. All subjects were classified according to the appearance of the glandular openings and the blood vessels on the endometrium surface into Group Ⅰ and Group Ⅱ. An ELISA kit specific for human LIF was used for LIF assay. Results:The median LIF concentrations measured in Group Ⅰ and Group Ⅱ were 14. 375±15. 155 pg/mL and 61. 696±44.127 pg/mL. The difference of LIF concentration was statistically significant (P0. 05) between Group Ⅰ and Group Ⅱ. But no significant difference between Group Ⅰ and the proliferative endometrium (11. 02±11. 07 pg/mL) was found. The average expression of LIF mRNA in Group Ⅰ was 0. 93 ±0. 20, and 1. 55 ± 0. 08 in Group Ⅱ. The expression of LIF mRNA in the endometrium from Group I was much lower than that from the decidua of early pregnancy (1. 65 ± 0. 18), while no significant difference was observed between Group Ⅱ and the decidua of early pregnancy. Conclusion;There is a strong relationship between endoscopic findings and the concentration of LIF. Our data suggested that the hysteroscopic appearance of the mid-secretory endometrium and measurement of LIF in uterine flushing are better evaluation factors for the uterine receptivity.
【CateGory Index】: R329
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【Co-references】
Chinese Journal Full-text Database 6 Hits
1 MENG Bin, LU Shu-lan, CAO Zuan-sun (Department of Gynecology and Obstetrics, The First Hospital of X i'an Jiaotong University, Shaanxi Xi'an 710061,China);Leukemia inhibitory factor and female reproduction[J];Foreign Medical Sciences Section of Maternal and Child Health;2005-02
2 ZHANG Wei,ZHOU Jian Ping,LIU Yin kun △,Wu Xin △ (Institute of Obstetrics and Gynecology Hospital,Shanghai Medical University,Shanghai 200011, △Liver Cancer Institute of Zhongshan Hospital,Shanghai Medical University,Shanghai 200032);Expression of Leukemia Inhibitory Factor mRNA and Its Localization in the Endometrium of Early Pregnant Mouse[J];JOURNAL OF SHANGHAI MEDICA(UNIVERSITY);2000-04
3 SONG En xue,ZHANG Wei,WANG Li (The Affiliated Obstetrical and Gynecological Hospital, Fudan University, Shanghai 200011, China);Progress in study on embryo implantation regulating mechanism of leukemia inhibitory factor[J];Foreign Medical Sciences Section of Maternal and Child Health;2004-06
4 LI Gang,WANG Ying xiong,LIU Xue qing, WENG Ya guang,HE Jun lin,CHEN Xue mei (Department of Genetics,Chongqing Medical University,Chongqing 400016,China);Expression of Leukemia Inhibitory Factor Gene in Decidua from Women with Habitual Abortion[J];Hereditas(Beijing);2002-03
5 LI Su-Chun,YAN Cai-Ping,SU Yun et al.Family Planning Research Institute of Guangdong,Guangzhou 510600,Guangdong,China;Relations between leukemia inhibitory factor(LIF) and endometrium on the window of implantation in women[J];Maternal and Child Health Care of China;2007-18
6 GUO Xiaoxia *, CHENG Qixin, WANG Yingxiong *?Department of Obstetrics and Gynecology, Sichuan Provincal People′s Hospital,Chengdu 610072,China;Expression of endometrial leukaemia inhibitory factor gene in patients with unexplained infertility[J];Chinese Journal of Obstetrics and Gynecology;2001-02
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