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《Reproduction and Contraception》 2003-06
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Relationship between Level of Serum Epithelial Growth Factor and Vaginal Bleeding Days after Medical Abortion

Xiu-pan NAN, xin WANG, Ming-hui WU Wei-ping LI, Ya-qin WANG, Jian-ying ZHAO (Beijing Obstetrics and Gynecology Hospital, The Affiliated Hospital of Capital University of Medical Sciences, Beijing 100006)  
Objective:To explore the relationship between the level of serum epithelial growth factor(EGF) and vaginal bleeding days after medi- cal abortion, and the effect of extra administration of mifeprostone or misoprofil on the EGF, hCG and vaginal bleeding days. Methods; A number of 90 women who were clinically diagnosed as early pregnancy and had no physical complication and inhibition of mifeprostone or misoprofil and wanted to terminate pregnancy by medicine, were randomly devided into 3 groups, who were respectively administered placebo, mifeprostone (50 mg) or misoprofil (200 μg) after routine medical abortion. Before first administration, serum EGF and hCG were assessed. Then 10 women were randomly choosen from each group, and their serum hCG were assessed after abortion. The relationship between EGF with HCG and vaginal bleeding days was analyzed. Results;A positive relationship was found between the serum EGF and vaginal bleeding days after abortion, EGF related to hCG (before abortion) (the relative coefficient is 0.428). Whatever was extra administrated, either 50 mg mifeprostone or 200 μg misoprofil, the vaginal bleeding days could be shortened significantly all the same (P0. 05). Conclusion: The level of serum EGF affect vaginal bleeding days, especially when the level of serum EGF is 2. 6 μg/dL, if extra 50 mg mifeprostone or 200 μg misoprofil was administered immediately after abortion, the vaginal bleeding days would be shortened significantly.
【CateGory Index】: R169.4
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