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《Chinese Journal of Reproduction and Contraception》 2017-12
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Induction of ovulation with clomiphene combined with bromocriptine in polycystic ovary syndrome patients with infertility: a prospective, randomized, controlled clinical trial

Guan Haiyun;Zhang Wei;Huang Bingqing;Obstetrics and Gynecology Hospital of Fudan University;Shanghai First Maternity and Infant Hospital, Tong Ji University;  
Objective To compare the effects of bromocriptine(BCT) combined with clomiphene citrate(CC)on the outcome of ovulation-induction in patients with polycystic ovary syndrome(PCOS). Methods A prospective,randomized, controlled clinical trial was performed on 100 PCOS patients with infertility. Patients were randomly divided into two groups, control group received 50 mg CC from day 3 to day 7, test group(CC+ BCT) was given 50 mg of CC from day 3 to day 7 along with 2.5 mg of BCT daily for full cycle. Both the groups were treated for one cycle.Results The outcomes were measured by the hormonal status, follicular size, endometrial thickness, ovulation rate, and pregnancy outcomes. The baseline level of hormones between the two groups was not different before treatment. After intervention, the rate of ovulation in CC group was 72.0% and in CC+ BCT group was 75.4%(P0.05), the rate of ongoing pregnancy in CC+ BCT group(18.4%) was higher than that in CC group(8.0%). On hCG injection day, there were no statistically significant differences between two groups regarding to levels of follicle-stimulating hormone(FSH), estradiol(E_2) and progesterone(P), but prolactin(PRL) and testosterone(T) was significantly decreased(respectively P=0.000,P=0.004), and LH level was also decreased but with no statistical significance(P=0.094). On hCG injection day 7, levels of P and E_2 were not different between the two groups(respectively P=0.901, P=0.192), but PRL level was decreased(P=0.000) and the endometrial thickness was increased significantly(P=0.017). Conclusion Our results showed that BCT plus CC can improve the outcome of ovulation-induction of PCOS patients, reducing levels of PRL, LH and T, and increasing the endometrial thickness of embryo implantation time. It can be concluded that use of BCT with CC improve the outcome of ovulation-induction more than use of CC alone for infertile PCOS patients, which may be brought about through dopamine agonists efficacy in reducing LH and PRL levels, vascular resistance and increasing uterine blood supply to the uterus.
【Fund】: 上海市科协项目(KXSH021311)~~
【CateGory Index】: R711.6;R711.75
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