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《Chinese Journal of Reproduction and Contraception》 2017-12
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Logistic regression analysis of risk factors associated with spontaneous abortion after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer in polycystic ovary syndrome patients

Li Xiaolan;Huang Rui;Fang Cong;Wang Yanfang;Liang Xiaoyan;Reproductive Medicine Center, the Sixth Affiliated Hospital of Sun Yat-Sen University;  
Objective To analyze spontaneous abortion rate and its associated risk factors in patients with polycystic ovary syndrome(PCOS) after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET). Methods This was a retrospective cohort study of patients undergoing IVF/ICSI treatment. A total of 2231 patients with PCOS were included. For comparison, we enrolled 2231 patients with tubular factors as control group. Spontaneous abortion rate and chromosomal abnormality rate were compared between the two groups.Furthermore, clinical data were compared between patients of spontaneous abortion and those of ongoing-pregnancy using univariate and multivariate analysis for risk factors of spontaneous abortion in PCOS patients. Results Patients in PCOS group had significantly higher spontaneous abortion rate(24.15%) than control group(12.75%, P0.001).Chromosomal abnormality rate was significantly lower in PCOS group(36.05%, 31/86) than in control group(55.56%,50/90, P=0.009). In PCOS group, patients of spontaneous abortion had older age, higher body mass index(BMI) and homeostasis model assessment for insulin resistance(HOMA-IR) than those of ongoing pregnancy. All the differences reached statistically significant. The further Logistic regression analysis confirmed that the age, BMI and HOMA-IR were risk factors of spontaneous abortion in PCOS patients. There were no significant differences in the type of cycles, the quality of embryos transferred, the number of embryos transferred, fasting blood glucose,fasting insulin, ect. Conclusion Compared with non-PCOS patients, PCOS patients had higher rate of miscarriage,but chromosomal abnormality was not a major factor for the high rate of miscarriage in PCOS patients. Age, BMI and HOMA-IR were risk factors for spontaneous abortion after IVF/ICSI-ET in PCOS patients.
【Fund】: 国家重大研发项目(2017YFC1001600);; 国家自然科学基金(81471507)~~
【CateGory Index】: R711.75;R714.8
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