Research progress on polycystic ovary syndrome and fat distribution
Lu Kun;Zhu Haiying;Luo Xiaorong;Zhang Xuehong;The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University, Key Laboratory for Reproductive Medicine and Embryo of Gansu Province;
Polystic ovary syndrome(PCOS) is the most common reproductive endocrine disease in women.Overweight/obesity can aggravate the metabolic status and reproductive disorders of PCOS women. Obesity and visceral fat accumulation are associated with chronic hypo-inflammatory status, PCOS patients are in a chronic inflammatory state. Inflammation can lead to insulin resistance(IR), and IR will lead to hyperandrogenism and increased androgen. IR and inflammation interact with each other, becoming a vicious cycle. Sex hormones affect the body fat distribution, PCOS patients in about 50% to 60% often manifested as male body fat distribution, the emergence of abdominal fat accumulation. IR, inflammatory response and abdominal obesity have the relationship between each other. Abdominal obesity may lead to IR and inflammatory response, IR and increased inflammatory response can also lead to abdominal obesity. Traditionally, adiposities are divided into white adiposities and brown adiposities. White adipose tissue(WAT) mainly distributed in the subcutaneous and viscera of the body, and strongly correlated with inflammation, IR and type 2 diabetes mellitus(T2DM). Brown adipose tissue(BAT) can increase energy consumption and generate heat, mainly in the scapular, surrounding and aortic deposits. BAT can improve the energy consumption of PCOS and glucose metabolism, reduce the level of related hormones, help to improve the menstrual cycle of PCOS patients and ovulation.
【CateGory Index】： R711.75