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《LiShiZhen Medicine and Materia Medica Research》 2006-08
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Studies on Fraction with Antidepressant Activity from the Flower of Albi zzia Julibrissin Durazz

LI Zuo-ping,ZHANG Man-li,MAO Zhi-juan,FAN Gui-min(School of Pharmacy,Hebei Medical University,Shijiazhuang 050017, China)  
ObjectiveTo screen the antidepressant fraction of the flower of Albizzia julibrissin Durazz(Hehuanhua).MethodsUsing the forced swimming test in mice,the antidepressant effect of different fraction from it was observed.ResultsThe petroleum ether fraction and ethyl acetate fraction from the aqueous and ethanol extracts of Hehuanhua can significantly shortened immobility time of mice in the forced swimming test.ConclusionThe petroleum ether and ethyl acetate fraction from the aqueous and ethanol extracts of Hehuanhua produces an antidepressant-like effect in the despair animal models of depression in mice.They maybe the active part of flower of Albizzia julibrissin Durazz.
【Fund】: 河北省自然科学基金资助项目(No.303470)
【CateGory Index】: R284
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