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《Lishizhen Medicine and Materia Medica Research》 2009-02
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Effect of Ziziphus jujube Leaf Extract on the Central Nervous System

ZHAO Xin-hua,YI Li-nan (Peking Union Medical College and Chinese Academy of Medical Sciene,Cancer Institute,Beijing,100021,China)  
Objective To study the pharmacological effects of the Ziziphus jujube leaf extract on central nervous system.Methods The pharmacological effects of the Ziziphus jujube leaf extract on the autonomic activities of mice,the time of sleep induced by pentobarbital sodium,the sleeping synergistic action of mice with barbital sodium at sub-threshold and hypnotic dosages and the central inhibitory effects in mice induced by amphetamine were investigated.Results The Ziziphus jujube leaf extract could inhibit autonomic activities of the mice,prolong the sleep time induced by pentobarbital sodium,enhance the rate of falling asleep induced by barbital sodium and inhibit the central stimulating effects induced by amphetamine.Conclusion The Ziziphus jujube leaf extract has significant sedative and anti-hyperspasmia effects.
【CateGory Index】: R285.5
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