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The Influence of Boschniakia rossica Extract on Learning and Memory Capability and Neuronal Apoptosis in AD Model Rats

ZHOU Li-sha1,ZHU Shu-xiu1,WANG Lu-shan2(1.Medical School of Jianghan University,Wuhan 430056,Hubei;2.Post-graduate of 2006,Hubei College of Traditional Chinese Medicine,Wuhan 430065,China)  
Objective To investigate the influence of Boschniakia rossica extract on learning,memory and neuronal apoptosis in AD model rats.Methods 60 healthy SD rats were randomly divided into normal group,sham group,the model group and the group of traditional Chinese medicine with high-dose,medium-dose and low-dose.To establish the AD model by Aβ1-40,give the traditional Chinese medicine groups were administered three different treatment doses of Boschniakia rossica extract:high,medium and low dose.After the treatment,rats learning,memory capability and the percentage of neuronal apoptosis were tested.Results The learning and memory capability in the group of traditional Chinese medicine rats is better than in the model group(P0.01),while the hippocampus and cortex parts neuronal apoptosis percentage is lower than the model group(P0.01).Conclusion The herb Boschniakia rossica extract to AD rats can effectively improve learning and memory obstacle,inhibit the cholinergic neuronal apoptosis.
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