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《Journal of University of Science and Technology of Suzhou》 1997-01
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Relationship Between Penicilline Seizure and Affinity of GABA_A and GABA_B Receptors of Brain in Mice

Xu Xianggui Wang Xuegin~* Fang Hua Zhu Jianqin~* Department of Biology,Suzhou Railway Teachers College,Suzhou 215009 * Department of Biological Science and Technology,Nanjing University,Nanjing 210093  
We studied the effects of penicilline seizure with intracerebroventricular microinjection penicilline on the affinity of GABA_A and GABA_B receptors in four brain areas: cerebral cortex,cerebellum,hippocampus,hypothalamus in mice.The results showed that the affinity of GABA_A receptor in both cerebral cortex and cerebellam was markedly weak- ened when penicilline seizure was developed,whereas the affinity of GABA_A receptor in hip- pocampus and hypothalamus had no change.The penicilline seizure significantly decreased the affinity of GABA_B receptor in all of four brain areas.These results suggested that besides GABA_A receptor in hippocampus and hypothalamus,all of other GABA_A and GABA_B recep- tors in the four brain areas participated in the development of penicilline seizure.Probably the penicilline blockeded the presynaptic and postsynaptic inhibition which was mediated by GABA through competing the GABA binding sites on GABA_A and GABA_B receptors with en- dogenous GABA,and increased the release of excitatory neurotransmitters from presynaptic membranes,thereby evoking the seizure.
【CateGory Index】: R96
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