Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《JOURNAL OF TIANJIN NORMAL UNIVERSITY (NATURAL SCIENCE EDITION)》 1995-03
Add to Favorite Get Latest Update

IN VITRO INVESTIGATION OF MONOCLONAL ANTIBODY-PHARMORUBICIN CONJAGATE FOR TARGETING THERAPY OF BREAST CARCINOMA

Gao Hong(Department of Biology,Tianjin Normal University)  
The preparation and immunoreactivity testing of the conjugate,monoclonal antibody to phamorubicin, were described in this article.The conjugation of pharmorubicin to monoclonal anti-breast cancer cell line antibody.using an intermediate polyaldehyde dextran carrier system,resulted in a ratio of 31 molecules of phamorubicin per molecule of immunoglobulin.The immunoreactivity of the conjugate was analyzed using enzyme-linked immunosorbent assay(ELISA), which showed that the conjugate has significant reaction of the antigenbinding activity.These studies offer the evidence for clininal experiment of monoclonal antibody drug conjugate.
【CateGory Index】: Q812
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Zhi-Nan, LIU Yan - Fang, SUI Yan - Fang, FU Cheng - Hua and XU Li-Qing Hepatoma Targeting Research Group, Department of Pathology;~(131)I-labelled anti - hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice[J];Journal of The Fourth Military Medical University;1991-03
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 SUI Yanfang,LIU Li,CHENG Zhinan,LIU Yanfang,WANG Wenliang(Department of Pathology, fourth Military Medical University,Xi’an 710032)[;AN EXPERIMENTAL STUDY OF HEPATOCELLULAR CARCINOMA IMMUNOTARGETTING DRUG WITH “DUAL WARHEAD”[J];CHINESE JOURNAL OF CANCER;1994-06
2 Liu Li, Sui Yanfang, Chen Zhinan, Liu Yanfang. Departrnent of Pathology, ForthMilitary Medical University. Xi'an , 710032;THE STUDY OF "DOUBLE LABELING MISSILE" TARGETTING-DRUG FOR HEPA-TOCELLULAR CARCINOMA[J];MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY;1994-01
3 Liu Bin, Sim Zhenqiang, Wu Junzheng, Chen Jianyuan & Wang Wei(Central Laboratory, College of Stomatology, The Fourth Military Medical University, Xi'an 710032 );Preliminary Study of Monoclonal Antibodies against Oromaxillofacial Tumor[J];Journal of Cellular and Molecular Immunology;1991-02
4 Sui Yan-Fang;Liu Li;Cheng Zhi-Nan et al(Department of Pathology, The Fourth Military Medical University, Xi-an);The Experimental Studies of "Double Bomb"-Mixed Monoclonal Antibody for Hepatocellular Carcinoma[J];CHINESE JOURNAL OF CLINICAL ONCOLOGY;1995-10
5 Sui Yanfang, Liu Li, Cheng Zhinan, et al. Department of Pathology, Fourth Military Medical University, Xi'an 710032;Experimental studies on targeting-therapy of "double bomb"-Mixed monoclonal antibodies immunoconjugates against hepatocellular carcinoma[J];Chinese Journal of Digestion;1996-S1
6 Sui Yan-fang;Liu Li;Wang Wen-liang et al(Department of Pathology,The Fourth Military Medical University, Xi-an);STUDY OF MONOCLONAL ANTIBODY CONJUGATED WITH DUAL-BULLETS FOR PILOT TREATMENTOF LIVER CANCER[J];TUMOR;1995-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved