Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Tianjin Pharmacy》 2009-03
Add to Favorite Get Latest Update

Related substance test and assay of cefixime and assay of cefixime in tablets or capsules by HPLC

Du Xu1,Feng Yong2,Cao Xiaoyun1(1.Tianjin Institute of Drug Control,Tianjin 300070;2.Tianjin Port Hospital,Tianjin 300456)  
Objective: To establish an HPLC method for quantitative determination of amount of cefixime and related substances,and amount of cefixime in tablets or capsules.Method: Cefixime was separated on ODS column with mobile phase of tetrabutylammonium hydroxide solution-acetonitrile(70∶30) and detected at 254 nm.Results: The standard curve was linear within the range of 0.06~0.30 mg/ml and the correlation coefficient was 0.999 9.The precision of cefixime was good(RSD was 0.7%,n=9) with the lowest detectable limit of 0.03 μg(S/N3).The average recovery of cefixime from its tablet and capsule was 99.5%(RSD was 0.5%,n=9) and 99.8%(RSD was 0.3%,n=9) respectively.Conclusion: the proposed method is simple,rapid,accurate and reliable.
【Key Words】: HPLC cefixime related substance tablet capsule
【CateGory Index】: R927.11
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved