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Dual Functions of Co-TPPS_4 in Scavenging Oxygen Free Radicals and Hydrogen Peroxide

Feng Qing; Liu Li; Zheng Qifang et al (Department of Chemistry,School of Basic Medical Sciences,Tongji Medical University,Wuhan 430030)  
In this article,the tetraphenylporphinesulfonatocobalt (Co-TPPS4) was used as dual function mimicry of superoxide dismutase (SOD) and catalase (CAT). The first function, scavenging O2, has been proved by using riboflavin-methionine photoreduction method in the concentration range of 10-5~10-6 mol/ L. The second function, scavenging H2O2, has been demonstrated by means of spectrophotometry. When the concentration of Co-TPPS4 increased from 5 μmol/L to 30 μmol/L, the decomposing rate of H2O2 increased from 11.9% to 62. 4%. Co-TPPS4, SOD and CAT were measured by the liver homogenate technique of mice and the results showed that they had obvious action of decreasing the lipid peroxidation.
【Fund】: 国家自然科学基金!No.39370794
【CateGory Index】: R392
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