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《ACTA UNIVERSITATIS MEDICTNAE TANGJI》 1997-05
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A Pathological Study of Isolated Liver Perfusion with Large Dose 5-Fu in Rats

Xing Xue; Xia Suisheng (Institule of Organ Transplantation, Tongji Medical University, Wuhan 430030)  
Isolated liver perfusion (ILP) in situ in rats using different doses of 5-Fu was performed to observe the pathological changes of the liver. The results showed that normal hepatic tissue could tolerate regional perfusion with not more than 250mg/kg of 5-Fu. The hepatic ultrastructures developed reversible changes in ILP with 150mg/kg of 5-Fu, which had no significant difference as compared with those of ILP without 5-Fu and total hepatic vascular blockage. From the above it can be seen that ILP within 5-Fu of the maximally tolerance is not likely to deteriorate ischemia-reperfusion injuries of hepatic tissues.
【CateGory Index】: R363
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【References】
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【Co-references】
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1 LIU Xin-Yuan1,2, GU Jin-Fa2 1. Xinyuan Institute of Medicine and Biotechnology, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310018, P. R. China 2. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P. R. China;A Mini-review of Targeting Gene-Virotherapy of Cancer[J];Chinese Journal of Cancer;2006-10
2 He Li, Mao-Ming Xiong, Xiang-Ling Meng, Xiao-Ping Geng, Department of General Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China;Reversing effect of arsenic trioxide on multidrug resistance of human hepatocellular carcinoma HepG2/ADM cells[J];World Chinese Journal of Digestology;2006-27
3 ZHU Anlong, LIU Lianxin, PIAO Daxun, et al. Department of General Surgery, First Affiliated Hospital, Harbin Medical University, Harbin 150001, P. R. China;Continuous regional chemotherapy using arsenic trioxide for primary hepatic carcinoma[J];Chinese Journal of Hepatobiliary Surgery;2003-04
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