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《ACTA UNIVERSITATIS MEDICTNAE TANGJI》 1997-05
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Role of Standardization of the Prothrombin Time in Monitoring Anticoagulant Therapy After Mechanical Prosthetic Valve Replacement

Du Xinling; Zhang Kailun; Hu Zhiwei et al (Institute of Cardiovascular Diseases, Tongji Medical University, Wuhan 430022)  
To evaluate the effects of thromboplastins from different sources on the prothrombin time (PT) test and the role of standardization of PT in monitoring oral anticoagulant therapy, PT assay was performed by using two kinds of homemade thromboplastins (one without providing information on the International Sensitivity Index, ISI, and the other with an ISI of 1. 2) and factor X determined before operation and on postoperative day 4, 7, and 14 in 20 patients with mechanical prosthetic heart valve who were treated with warfarin. The results showed that the activity of factor X was limited effectively during maintenance anticoagulant therapy, but the difference between prothrombin time ratios determined using different reagents existed on postoperative day 7 and 14. The present study suggests that reliance on prothrombin time ratio (PTR) to adjust anticoagulation can cause significant errors and International Normalized Ratio (INR) is of great importance to ensure clinical efficacy and safety of oral anticoagulant therapy in patients with mechanical prosthetic heart valves.
【CateGory Index】: R654.2
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Chen Baoliang; Gu Xiaolin;Peng Mingting,et al ( National Center for Clinical Laboratory, Beijing 100730);A survey of prothrombin time assay in China[J];CHINESE JOURNAL OF MEDICAL LABORATORY SCIENCES;1995-02
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 Yuan Baixiang,et al Department of Clinical Labartory,First Affiliated hospital, Dalian Medical University;The use of domestic hare-brain-tissue-thromboplastin replacing import hare-brain-tissue-throm boplastin on ACL3000 instrument[J];JOURNAL OF DALIAN MEDICAL UNIVERSITY;1997-02
2 Xiao Shiliang ;Hu Zhiwei; Cai Jungian et al (Institute of Cardiovascular Disease,Tongji Medical University,Wuhan 430022);Prosthetic heart valve replacement in children[J];JOURNAL OF CLINICAL CARDIOLOGY;1998-06
3 Deng Fugui et al(Department of Hematology );EXTRACTION OF TISSUE THROMBOPLASTIN FROM HUMAN PLACENTA AND ITS QUALITY EVALUATION[J];JOURNAL OF SICHUAN CONTINUING EDUCATION COLLEGE OF MEDICAL SCIENCES;1995-04
4 GUAN Ming, L Yuan, NI Zan\|ming (Department of Clinical Laboratory,Hua Shan Hospital,Shanghai\ 200040,China) WANG Yun\|gui, DAI Jin\|feng, CHEN Chang\|qing (Shanghai Center of Biotechnology,Chinese Academy of Sciences,Shanghai\ 200233,China);Cloning,Expression and Purification of Extracellular Domain of Tissue Factor and Activity Analysis of Its Product[J];Chinese Journal of Biochemistry and Molecular Biology;2001-01
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