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A Study of the Effects of Combination Chemotherapy on Bladder Cancer Cell Lines BIU-87 in Vitro

Chen Zhong; Li Jiagui;Yang Yiejin et al (Department of Urology,Tongji Hospital,Tongjj Medical University, Wuhan 430030)(Department of Medical Molecular Biology, Research Center of Experimental Medicine,Tongji Medical University, Wuhan 430030)  
This study was carried out to evalute the interactions of mitomycin C (MMC), adriamycin (ADM), hydroxycamptothecine(HCPT) and thiotepa(TSPA) against a human bladder cancer cell line BIU-87 by using the MTT assay in vitro. Results showed that combination of HCPT and MMC or ADM had the better synergistic cytotoxicity. In groups with continuons drugs using, the ratios of the median lethal dose between expectancy and actual result were 13. 59、11.26.In groups with sequential drug using, when HCPT was used first, followed by MMC, ADM or TSPA, the inhibition rate was obviously higher than when a single drug in the same dose was used. However, combination chemotherapy can increase cytotoxicity against BIU-87 line.
【CateGory Index】: R737.14
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