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Experimental Study on the Prevention and Treatment of Mesangial Proliferative Glomerulonephritis in Rabbit by API_(0134)

Wu Hengsheng; Wang Hongwei; Xu Qinru et al (Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan 430030)  
Rabbit mesangial proliferative glomerulonephritis model was established to investigate the effects of API0134 on the levels of blood-lipid, superoxide dismutase (SOD) and molondialdehyde (MDA), and on the kidney tissues. Their mechanism was also explored. The results demonstrated that the levels of serum total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) in API0134 group were lower than those in model group (P0. 05), while the ratio of high density lipoprotein (HDL-C) to LDL-C in API0134 group was obviously higher than that in model group (P0. 01). The level of MDA was normal. The kindey lesions in API0134 group were significantly alleviated. It was suggested that API0134 might effectively prevent experimental hyperlipidemia, have anti-oxygenating effect, inhibit the proliferation ofmesangial cells and protect the kidney tissues from being injured in rabbit.
【CateGory Index】: R285
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