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The Effects of Primary Cytomegalovirus Infection on Fetal and Infant Development in Early Pregnancy

Zeng Wanjiang; Wen Liangzhen; Qian Xiaohu et al (Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical University, Wuhan 430030)  
Twenty pregnent women with primary human cytomegalovirus (HCMV) infection in the first trimester were studied by Enzyme-linked immunoaborbed assay (ELISA) and polymerase chain reaction (PCR) with 49 cases of recurrent HCMV infection and 386 cases of previous HCMV infection in the second trimester or the third trimester serving as control. The primary infection rate was 4. 21%. In 20 cases of HCMV infection, their babies were diagnosed as congenital CMV infection. CMV-DNA was detected positive in amniofluid, cord blood, newborn external blood, urine or tissues of autopsy. The intrauterine transmission rate was 75.0 % (15/20). The rates of IUGR, stillbirth and congenital malformation were 20.0%, 5.0% and 10.0% respectively. The difference between primary infection group and recurrence infection group or previous infection group was statistically singnificant. The MDI (mental development index) of 10 babies of the mothers having primary CMV infection was lower than those of the other 13 babies of the mothers having recurrence CMV infection and 34 babies of the mothers having previous CMV infection and the difference was significant (P0. 05). But the difference of PDI among three groups was n0t statistically singnificant (P 0. 05). The influence of primary CMV infection of pregnant women in the first trimester on their fetuses and infants was more severe than that of recurrent infection and previous infection. Serum screening for CMV-IgM, IgG of pregnant women was very important in the first trimester.
【Fund】: 国家“八五”攻关项目!No.85-918-06-08
【CateGory Index】: R715
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