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《ACTA UNIVERSITATIS MEDICTNAE TANGJI》 1997-05
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Effects of Rotundine on Cytosolic Free Calcium Concentration in Porcine Pulmonary Artery Smooth Muscle Cells

Cheng Longxian;Mao Huanyuan;Hu Qinghua (Institute of Cardiovascular Dieases, Tongji Medical Universny, Wuhan 430022)(Department of Pathophysiology, School of Basic Medical Sciences, Tongji Medical Universny,Wuhan 430030)  
Effects of Rotundine on cytosolic free calcium concentration ([Ca2+]i) were studied in cultured porcine pulmonary artery smooth muscle cells by using the fluorescent Ca2+-indicator Fura-2/AM. It was found that Rotundine inhibited the elevation of [Ca2+]i induced by potassium-depolarization and calcium agonist Bay K 8644 in a concentration-dependent fashion. No significant effect on resting [Ca2+]i was found.Effects of Rotundine on [Ca2+]i were similar to but weaker than those of verapamil. These results suggest that Rotundine may decrease the [Ca2+]i, of smooth muscle cells by blocking voltage-dependent calcium channels,which is one of its hypotensive mechanisms.
【Fund】: 湖北省教委科研计划项目!No.C044
【CateGory Index】: R965
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Fang Xianming;Bei Weijian(Guangxi College of TCM)Qian Hailing;Huang Liwu;Li Xiguang(The First Affiliated Hospital of Guangxi College of TCM);Clinical Observation on Angina Pectoris of Coronary Heart Disease Treated with An Xin Oral Solution-Contrast Analysis of 73 Cases[J];GUANGXI JOURNAL OF TRADITIONAL CHINESE MEDICINE;1995-06
2 GE Huaizhen, LI liping, LIU Hui. Baoding TCM Hospital, Hebei Province 071000;Clinical observation on Xintongning oral liquid for the treatment of angina pectoris[J];HEBEI JOURNAL OF TRADITIONAL CHINESE MEDICINE;2000-04
3 Lai Zheng;et al(Shenxheng People's Hospital 518000);MICROCIRCULATION OF QI WEAKNESS WITH BLOOD STASIS AND QI CONGESTION WITH BLOOD STASIS IN ANGINA PECTORIS[J];JOURNAL OF HUNAN COLLEGE OF TRADITIONAL CHINESE MEDICINE;1994-03
4 ZHU Zhong yu, LI Wei, GAO Chuan yu, et al. Department of Cardiology, Henan Provincial People's Hospital,Zhengzhuo 450003,China;Dyslipidemic feature in Chinese patients with coronary heart disease[J];Clinical Focus;2003-09
5 SONG Wei WANG Binyao WANG Changqian LI Jinghua XIE Xiulan DING Hongyi XU Yimin (Department of Cardiology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001);Clinic assessment of the level of serum anti-ox-LDL with the prognosis of coronary heart disease[J];Journal of Clinical Cardiology;2002-04
6 GUO Yuan-biao,ZHENG Lan,ZHU Wei-rong,GU Tao (TCM Department,Ruijin Hospital Affiliated to Shanghai Secondary Medical University,Shanghai 200025,China);Clinical Research on Method of Freeing the Network Vessels and Boosting Qi in the Treatment of Coronary Heart Disesase with Angina Pectoris[J];Liaoning Journal of Traditional Chinese Medicine;2001-08
7 ZHANG Huan,WANG Yi-tao,YAN Can,ZHANG Qing-wen,LI Shao-ping(1.Macau University,Macau,China;2.Traditional Chinese Medccine Unversity of Guangzhou,Guangzhou 510006,China);Rerearch Progress and Comparison between the Pharmacological Effect of Radix Angelica Sinennsis and Rhizoma Chuanxiong[J];Lishizhen Medicine and Materia Medica Research;2008-02
8 Zhang Ping, Shen Yufang,Chen Danian,Wang BangningNan Danping,Liu Hejun,Liu Min,Huang Qizhi (Affliated Hospital,Anhui Medical University,Hefei 230022);THE COMPARISON OF HEART-PROTECTING MUSK FIILS AND ISOSORBIDE DINITRATRS IN THE TREATMENT OF ANGINA PECTORIS[J];Natural Product Research and Development;1997-02
9 JT Zhang, Y Liu, ZW Qu, XL Zhang~* and HL Xiao~(**) (Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing);INFLUENCE OF GINSENOSIDE Rb_1 AND Rg_1 ON SOME CENTRAL NEUROTRANSMITTER RECEPTORS AND PROTEIN BIOSYNTHESIS IN MOUSE BRAIN[J];Acta Pharmaceutica Sinica;1988-01
10 Zhang Lianji;Feng Xin-e,et al.(Shijiazhuang Second Hospital,Shijiazhuang,050051);Investigation on Curative Effect of Meiluoning(Radix Scropulariae,Radix Achyranthis Bidentatae,etc.)for Coronary Heart Disease[J];CHINESE TRADITIONAL PATENT MEDICINE;1994-07
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