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《Tianjin Journal of Traditional Chinese Medicine》 2018-02
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Effect of Shengji Xiangpi mastic on diabetic ulcer rats Ang/Tie-2 pathway

LIU Peng;ZHU Zizhao;CHANG Bai;LI Qiaofen;Tianjin University of Traditional Chinese Medicine;Tianjin Medical University Metabolic Diseases Hospital;  
[Objective] Through the dynamic observation of diabetic ulcers Tie-2, Ang-1 and Ang-2 transcriptional level, to investigate the effect of Shengji Xiangpi mastic on diabetic ulcer rats Ang/Tie-2 pathway. [Methods] The first step is having an injection of STZ at rats' tail vein and back drilling prepared ulcer refractory animal model of T2 DM, according to blood glucose and body weight were randomly divided into diabetic group, saline group, Shengji Xiangpi mastic group and normal control group. Shengji Xiangpi mastic group used Shengji Xiangpi mastic gauze topical ulcer, vaseline group with vaseline gauze, control group, diabetic control group with saline gauze group, on the first day and in 3 days, 7 days after trauma, 14 days and 21 days respectively were part of rats. And take the ulcer tissue expression of Ang-1, Ang-2 and Tie-2 transcriptional level were detected by Western Blotting method in ulcer tissue. [Results]Shengji Xiangpi mastic group were higher than those of other groups of Ang-1 and Tie-2 transcriptional level at different time points in granulation tissue, the expression level of Ang-2 was lower than that of other groups(P0.05). [Conclusion] Shengji Xiangpi mastic may through increase wound granulation tissue in Ang-1, the expression of Tie-2, inhibit the expression of Ang-2 in diabetic rats, and promote ulcer surface angiogenesis, accelerate the healing of diabetic ulcers.
【Fund】: 国家自然科学基金项目(81373846);; 天津医科大学重点实验室开放项目(2016DX002)
【CateGory Index】: R285.5
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