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《Natural Product Research and Development》 2004-04
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STUDY ON THE ANTIVIRAL ACTIVITIES OF CONDENSED TANNIN OF ARTEMISIA ANNUA L.

ZHANG Jun-feng,TAN Jian,PU Qiang,LIU Ying-hua,LIU Yue-xue,HE Kai-ze * (Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,China)  
Inhibitory effects of condensed tannin of Artemisia annua L.(CTA) on herpes simplex virus type 2(HSV-2) and HBeAg secretion in cultured HepG2.2.1.5 cell line were investigated.When the anti-HSV-2 activity of CTA was tested with acyclovir(ACV) as contrast drug,CC 50 of CTA and ACV were 6.84 mg/mL and 3.69 mg/mL,IC 50 were 0.162 mg/mL and 0.138 mg/mL respectively.The results showed CTA was as effective as the clinical drug-ACV.To study the anti-hepatitis B virus activity of CTA,the cytotoxicity to 2.2.1.5 cell line and inhibition of HBeAg secretion were tested.The results showed that CTA had slight cytotoxicity at 2.5 mg/mL and can distinctly inhibit the secretion of HBeAg in HepG2.2.1.5 cell line.All the results indicated that CTA maybe have a high selectivity index against HSV and HBV.
【CateGory Index】: R285
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10 SUN Xia1,LIAO Xue-pin1,2,SHI Bi2 (1.Department of Biomass Chemistry and Engineering,Sichuan University,Chengdu 610065,China;2.National Engineering Laboratory for Clean Technology of Leather manufacture,Sichuan University,Chengdu 610065,China);Adsorption Behaviors of Collagen-Tannin Resin for Removing Hg(Ⅱ) in Aqueous Solutions[J];Journal of Chemical Engineering of Chinese Universities;2010-04
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7 PALIDA·Abulizi,MI Ren-sha,CONG Yuan-yuan,YIBA Daiti,WANG Xiao-wen(College of Pharmacy,Xinjiang Medical University,Urumqi 830054,China);Isolation and identification of chemical constituents in Ocimum bacilicum L.[J];West China Journal of Pharmaceutical Sciences;2007-05
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10 Jiang Huidi(College of Pharmaceutical Science, Zhejiang University, Hangzhou 310031) Xia Qiang, Xu Wanghong and Cao Chunmei (Department of Physiology, School of Medical Science of Zhejiang University);Studies on Cardiac effects of Chrysanthemum morifolium Ramat and Their Underlying Mechanisms[J];;2002-02
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