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GLOBAL STABILITY FOR A TWO-STRAIN VIRUS INFECTION MODEL WITH INTRA-CELLULAR DELAY AND IMMUNE RESPONSE

Zhaohui Yuan;Peipei Shang;Lingling Liu;College of Math.and Econometrics,Hunan University;  
Considering the immune response and intracellular delay,we propose a two-strain virus model and investigate dynamics of this mathematical model.The global dynamics of the model are completely determined by introducing suitable Lyapunov functionals.We show that if the basic reproduction number is less than one,then both strains die out;but when the number is greater than one,at least one of the strains become endemic depending on the parameter values.The theoretical results provide some useful information on the dynamics of the two strains virus.
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