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Inhibitory Effect of Nano-HA Particles on Human U87 Glioblastoma Cells Viability

TIAN Ang 1,WANG Chao2,XUE Xiang-Xin1,WU An-Hua2,GUAN Ge-Fei 2,WANG Li 1,QIU Bo2(1.School of Materials and Metallurgy,Northeastern University,Shenyang 110004,China;2.Department of Neurosurgery,the First Affiliated Hospital,China Medical University,Shenyang 110001,China)  
To evaluate the effects of Hydroxyapatite nano-particles(nano-HA) with different morphologies on human U87 glioblastoma cell line(U87),three kinds of nano-HA were designed and synthesized,and a co-culture system containing nano-HA and U87 cells was established.Polyethylene glycol(PEG) was also added to the HA medium system for the samples stabilization.After determining the stabilization and high dispersed nanometer size of nano-HA in the medium system using Transmission electron microscope(TEM) and dynamic light scattering(DLS),the effects of nano-HA on GBM cells were assessed with an MTT method.Results showed that nano-HA could effectively inhibit U87 cells proliferation.Compared with other nano-HA,the needle-like nano-HA were more powerful in inhibiting U87 cells proliferation.Toll-like receptor 4(TLR4) induced by different nano-HA may be one reason for their different bioactivity.
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