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Study on Preparation and Properties of Self-setting Silicon Hydroxyapatite Bone Cement

SU Jia-Can,CAO Lie-Hu,YU Bao-Qing,WANG Zhi-Wei,CHEN Xiao,LI Ming (Department of Orthopaedics,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)  
Silicon hydroxyapatite cement(s-HAC) was prepared by using the mixed powders of tetracalcium phosphate and dicalcium phosphate anhydrous,and 5wt%sodium silicate water solutions as cement liquid.The results show that the setting time of s-HAC is shorter than hydroxyapatite cement(HAC),and the compressive strength of s-HAC is higher than HAC in the same situation.The XRD results reveal that the finally hardening product of s-HAC is hydroxyapatite structure,which is similar to that of HAC.The s-HAC in the could release calcium (Ca),phosphorus(P) and silicon(Si) ions.The in vitro degradability of s-HAC in Tris-HCl solution is better than that of HAC.The cell culture experimental results indicate that the cell can attach on both the surfaces of s-HAC and HAC,and have good cell morphology.The optical density(OD) and alkaline phosphate(ALP) activity of MG_(63) cells on s-HAC are significantly higher that that of HAC,indicating that the s-HAC could promote the cell proliferation and differentiation.
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