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Study on the Loading and Releasing Behavior of Epirubicin Hydrochloride from Mesoporous Bioactive Glasses(MBGs)

ZHOU Yan-Ling,FENG Xin-Xing,ZHAI Wan-Yin,CHANG Jiang (Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China)  
Mesoporous bioactive glasses m58S were loaded with an anticancer drug-Epirubicin hydrochloride(EPI) and the release of the drug from the glasses was evaluated.The drug loading capacity of m58S for EPI was 40%, which was three times higher than that of conventional Sol-Gel bioactive glasses 58S.In phosphate buffered saline (PBS),the m58S-EPI system showed a sustained release behavior.Furthermore,the release rates from the EPI-m58S system increased with the decrease of pH values of the release medium.The results suggest that m58S is an effective anticancer drug carrier and its pH-related release behavior suggests that it has potential for design of controlled drug delivery bone grafting materials.
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