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Study of Fibroblast and Platelet Adhesion on Multi-wall Carbon Nanotubes

ZHAO Meng-Li~1,YUE Yu-Chen~1,YUAN Li~1,LI De-Jun~1,Lü Xiao-Ying~2,HUANG Yan~2 (1.College of Physics and Electronic Information Science,Tianjin Normal University,Tianjin 300387,China;2.State Key Laboratory of Bioelectronics,Southeast University,Nanjing 210096,China)  
Multi-walled nanotubes(MWCNTs) were grown on carbon papers by chemical vapor deposition(CVD). Adhesion and proliferation of L929 mouse fibroblasts and platelets on MWCNTs and carbon papers were investigated. The influence of different blood protein adsorption on the human skin fibroblasts growth was also studied. The results showed that mouse fibroblasts implanted on MWCNTs tended to grow more prolifically than those on carbon papers.The cell concentration observed on MWCNTs increased from 1.25×10~5/mL(cultured for 1 d) to 4.1×10~5/mL(culture for 7 d).No toxicity reaction was observed during the culturing period.By employing the adsorption assay,it was found albumin,fibrinogen,and immunoglobulin G adhered on materials could promote the adhesion and growth of the human skin fibroblasts.Furthermore,platelet adhesion rate on MWCNTs is lower than that on the carbon papers.These results indicate that MWCNTs have better tissue compatibility and blood compatibility.
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