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《Journal of Wuhan University(Natural Science Edition)》 2015-01
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A Novel Transdermal Drug Delivery System—IbuprofenBacterial Cellulose Membrane

HUANG Fang;HUANG Lin;YANG Guang;Hospital of Huazhong University of Science and Technology;Wuhan East Lake High-Tech Development Zone Administrative Committee;Department of Life Science and Technology,Huazhong University of Science and Technology;  
Bacterial cellulose(BC)was used as the carrier for ibuprofen to produce a controlled release system.Drug release studies and transdermal experiments were carried out in vitro to study its sustained release and transdermal properties.The results showed that:carrier BC could significantly extend the drug release time compared with commercially available ibuprofen tablets;mechanism of drug release was the dual role of the cellulose backbone swelling and the hydrogen between drug molecules and cellulose chains.By screening penetration enhancers,propylene glycol was the best one for promoting drug through BC membrane.As a transdermal formulation carrier,BC released drug at a slow and constant speed,which could both avoid skin stimulation caused by the high concentration of drugs released in a short time,and adjusted the bioavailability of the drug.Therefore,BC had great advantage compared with commercially available ibuprofen gel.
【Fund】: 国家自然科学基金(21074041);; 华中科技大学医工、医理交叉基金(0125170002)资助项目
【CateGory Index】: TQ460.1
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【References】
Chinese Journal Full-text Database 1 Hits
1 LV Hong-Hao;XIA Xiu-Fang;DANG Miao-Miao;FEI Nan;WANG Ying-Nan;WU Lei;College of Food Science, Northeast Agricultural University;Techcooper Biological Technology Co., Ltd.;Institute of Scientific and Technical Information of Heilongjiang;;Properties and application of bacterial cellulose[J];食品安全质量检测学报;2015-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HUANG Fang;HUANG Lin;YANG Guang;Hospital of Huazhong University of Science and Technology;Wuhan East Lake High-Tech Development Zone Administrative Committee;Department of Life Science and Technology,Huazhong University of Science and Technology;;A Novel Transdermal Drug Delivery System—IbuprofenBacterial Cellulose Membrane[J];武汉大学学报(理学版);2015-01
2 DENG Mao-cheng;WANG Yao;LI Jing;WU Yong-hui;ZHANG Yuan-ping;Department of Food and Biological Engineering, Guangdong Industry Technical College;Guangzhou Yide Biotechnology Co., Ltd.;Guangzhou Sugarcane Industry Research Institute;;SCREENING,IDENTIFICATION AND PRODUCT ANALYSIS OF A BACTERIAL CELLULOSE-PRODUCING STRAIN[J];河南工业大学学报(自然科学版);2014-05
3 LI Jun;LIU Si-xin;BI Ji-cai;HU Xiao-ping;LIU Long-xiang;DENG Jian;YANG Yi-chong;LI Cong-fa;College of Food Science and Technology,Hainan University;;Effects of potato starch on sphere-like bacterial cellulose produced by Komagataeibacter nataicola sp.Y9 in agitated culture[J];食品与发酵工业;2014-09
4 LAN Shui;TANG Xiao-yan;CHEN Lin;HONG Feng;Group of Microbiological Engineering and Industrial Biotechnology, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University;Nanjing Institute of Environment Sciences,MEP;;Improved Production of Bacterial Cellulose from Cassava Starch Hydrolysate and Pretreated Molasses by Agar Addition in a Submerged Mechanical Agitating Fermentation[J];纤维素科学与技术;2014-03
5 Wen Xiaoxiao;Zheng Yudong;Wu Jian;Zhang Tao;Chen Xiaohua;School of Materials Science and Engineering, University of Science and Technology Beijing;;Preparation and Characterization of Nano-silver/Oxidized Bacterial Cellulose Composites[J];稀有金属材料与工程;2014-S1
6 CHEN Jing;FENG Lei;YANG Xin-ping;Microbiology Institute of Xinjiang Academy of Agricultural Sciences;;Progress of Preparation and Application of Bacterial Cellulose[J];纤维素科学与技术;2014-02
7 LI Bin;ZHONG Chunyan;WANG Xibin;WANG Zhiguo;XIANG Dong;College of Food Science and Technology,Hainan University;Hainan Yeguo Foods Co.,Ltd.;;Comparison between coconut water and pineapple juice for bacterial cellulose production[J];中国酿造;2014-06
8 WANG Li-Fen;LI Zheng;JIA Shi-Ru;ZHANG Jian-Fei;Key Laboratory of Advanced Textile Composites,Ministry of Education,Textile Division,Tianjin Polytechnic University;Key Laboratory of Industry Microbiology,Ministry of Education,College of Biotechnology,Tianjin University of Science & Technology;;The research progress in characteristics and applications of bacterial cellulose[J];微生物学通报;2014-08
9 LU Min;L Xuan;GUAN Xiao-hui;School of Chemical Engineering,Northeast Dianli University;;The Influence of Buffer Capacity of Dried Corn Steep Liquor Powder on the Fermentation of Bacterial Cellulose[J];食品研究与开发;2014-01
10 HUANG Li;WANG Ying-nan;XIA Xiu-fang;DING Yi;YANG Ming;WANG Song;College of Food Science,Northeast Agricultural University;Haerbin Tian Tuo Sheng Wu Ke Ji Co. Ltd.;;Basic Characteristics and Application of Bacterial Cellulose[J];包装与食品机械;2013-05
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