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《Chinese Journal of Gastroenterology》 2018-05
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Accurate Understanding of Pathological Profile in Systemic Lupus Erythematosus With Liver Damage

GUO Ruru;L Liangjing;Department of Rheumatology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University;  
Systemic lupus erythematosus( SLE) is a prototypic autoimmune disease characterized by multisystemic organ involvement and production of multiple autoantibodies. The clinical manifestations of patients varied,ranging from mild joint pain and skin involvement to life-threatening internal organs involvement. In clinical practice,it is not common to have severe liver damage or even fulminant hepatic failure due to SLE disease itself. Liver is not the main organ to be involved in SLE,but abnormal elevation of liver enzyme is common in SLE. Liver biopsy is the gold standard for definite diagnosis. This article summarized the current reports of SLE with liver damage and analyzed the pathological changes of liver lesions due to SLE disease itself for improving the understanding of histopathology profile of SLE complicated with liver damage.
【Fund】: 国家重点研发计划(2017YFC0909002);; 上海交通大学医学院高峰高原计划—“研究型医师”以及“临床专职科研队伍”项目(20152214)
【CateGory Index】: R593.241
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