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《Journal of Toxicology》 2008-03
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Study on the two-generation reproductive toxicity of paclobutrazol in SD rats

CHEN Run-tao,DENG Ying-yu,CHEN Xiao-yan,HUANG Jian-xun,HUANG Zhen-lie(Guangdong Prevention and Treatment Center for Occupational Diseases,Guangzhou Guangdong 510300,China)  
Objective To investigate the reproductive and developmental effects of paclobutrazol in rats over multiple generations.Methods F0 and F1 parent rats were fed to paclobutrazol at the doses of 0,41.4,128.0 and 421.2 mg/(kg·d) for 8 weeks prebreed.Weights of main organs,breeding indexes and pathological changes were observed in F0 and F1 parents.The growth indexes of the offspring were measured and F1/F2 weanlings were necropsied with reproductive organs weighed.Results At 128.0 and 421.2 mg/(kg·d) groups,body weights of pregnant rats were decreased and some breeding indexes including fecundation index,survival rates of newborns and weanlings were changed,as well as pathological findings were found in testes.Conclusion Paclobutrazol affected the reproductive and developmental abilities of rats,and the no-observe adverse effect level(NOAEL) of two-generation reproductive effects is 41.4 mg/(kg·d).
【CateGory Index】: R114
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