Rapid Interruption of Perinatal Transmission of Plasma-Derived Hepatitis B Vaccine
Zheng Jumei et al (Lanzhou Institute of Biological Products,Lanzhou 730046)
The interruption of perinatal transmission with 30μg pes dose plasma-derived hepatitis B vaccine was studied between 68 infants of HBsAg positive mother immunized by 0、2、6 weeks and 31 infants of HBsAg positive mother immunized by 0、1、6 month.The results showed that both the group immunized with HBIG+HB vaccine and the group immunized with HB vaccine alone produced immune response. The seroconversion rates of antiHBs (10mIU/ml) were 91.89%, 83.87% and 81.08%, 83.87% at T6m,T12m respectively. The effective rate of anti-HBs were 19.35 %,83.87% respectively at T6w、T6m after 0. 2、6weeks vaccination which were obviously higher than that of vaccines with 0、1、6 months (being 2.23% versus 19.35%)(P0.01),but both were not obviously differance significance at T12m It showed that the short immunization schedule could early induce to produce protective anti-HBs.
【CateGory Index】： R392-33