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《Progress In Microbiology and Immunology》 2001-01
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Prediction of the HLA epitopes of T cells antigen on superantigen of staphylococcal enterotoxin A,B and C1

YANG Lian jun,SI Xiao hui(Department of Pathology,Fourth Military Medical University,Xian 710032)  
In order to predict the HLA Ⅰ and HLAⅡ epitopes on SEA,SEB and SEC1 of the superantigen staphylococcal enterotoxin(SE) family,and study the mechanism of SE activating T cells,predict the T cell epitopes of SEA,SEB and SEC1 according to their published complete sequences by using Guotif 2.0 T cell epitopes predicting software,with which the frequences were processed by statistics,to compare with the frequences occurred in the three types of peptide binding to motifs of HLA class Ⅰ and Ⅱ molecules.The results showed all three binding mainly to A3 motif of class Ⅰ molecule and DRⅠ motif of classⅡ molecule.There are in high degree of homogenecity among the three binded epitopes on HLA class Ⅰ and Ⅱ molecules.This study is a fundamental work for the experimental approach on the mechamism of SE activating T cells.
【CateGory Index】: R446.62
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Yang Lianjun,Sui Yanfang,Chen Zhinan(Fourth Military Medical University,Xi'an 710032);Establishment of the method of enhancing the total sequence of staphalococcal enterotoxin A gene with PCR and its significance[J];微生物学免疫学进展;1998-04
2 ZHANG Jian Ping, ZHU Yong, ZHANG Ting Ting, SUN Kai, LIU Fei, JIN Bo Quan (Department of Immunology, the Fourth Military Medical University, Xi’an 710032);Prediction of epitopes on HFRSV nucleocapsid protein and M polyprotein precursor restricted by H 2 d and H 2 b class Ⅰ molecules[J];细胞与分子免疫学杂志;1998-04
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 MA Li ying, YUE Bing fei (National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050, China);Advances in Research on Major Histocompatibility Complex[J];中国比较医学杂志;2005-03
2 YANG Lian jun,SI Xiao hui(Department of Pathology,Fourth Military Medical University,Xian 710032);Prediction of the HLA epitopes of T cells antigen on superantigen of staphylococcal enterotoxin A,B and C1[J];微生物学免疫学进展;2001-01
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