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Study on the influence factor of residual moisture in freeze-dried attenuated measles live vaccine during storage

XU Bin,WANG Tao,ZHOU Yuan,et al.(Lanzhou Institute of Biological Products,Lanzhou 730046,China)  
Many factors make the impacts on the residual moisture of the freeze-dried products,among them,the moisture content of cilin rubber stopper is a critical factor.The moisture contents of attenuated measles live vaccines were determined in the case of using dry-heat treated and non-treated rubber stopper.The result showed that the average moisture content of freeze-dried products is 2.03% and 0.08% respectively corresponding to use non-treated stoppers and treated ones after storage for 18 months.There is significant difference between two groups by the variance analysis of single factor(P0.01).This experiment proves the evidence that dry-heat treated rubber stopper can play a clear effect for maintaining the stability of the residual moisture in freeze-dried attenuated measles live vaccine during storage.
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