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Assessment of immune effect of Hepatitis B vaccine in newborns in 1992-2007 in Guangzhou

LI Zhi-qun,WANG Ming,CAI Yan-shan,et al.(Guangzhou Center For Disease Control And Prevention,Guangzhou 510080,China)  
To assess the immune efficiency of Hepatitis B(Hep B) vaccine in newborns after introducing Hep B vaccine into the EPI management.2877 newborns immunized with Hep B vaccine born in 1992-2007 were divided into two groups.The subjects born in 1992-2001 before EPI management were merged into group I,the subjects born in 2002-2007 after EPI management were merged into group Ⅱ.Blood samples were collected for detecting HBsAg,anti-HBs and anti-HBs.The results showed that HBsAg positive rate of group Ⅱ and group I is 0.48% and 4.54% respectively.The difference between two groups is of the statistical significance.The anti-HBs positive rate of group Ⅱ is 75.19% which is higher than that of group I.The immune efficiency of HepB in neonatal population after introducing HepB vaccine into EPI management is better than before EPI management.There are not statistical differences between the effect of different HepB vaccine types.The immunogenicity and short-term protective effect of recombinant yeast hepatitis B vaccine is excellent and can compare with the traditional blood-derived hepatitis B vaccine.
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