Study on immunity of polymerized botulinum type A toxoids and its preparation
CAO Xin-yun,HE Yan-lin,Gao Jian-jun,et al.(Lanzhou Institute of Biological Products,Lanzhou 730046,China)
To prepare the polymerized botulinum type A toxoids,EDC was used as carriers and investigate theirs immunogenicity and reactivity.BALB/c mice were immunized with this polymerized preparation and induced a strong and specific response.The dynamic antibody level in serum was monitored by an indirect ELISA.There are great senses to illustrate the mechanisms of action of botulinum neurotoxin A –type antigen polymerized in order to obtain the therapeutic neutralizing antibody.
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