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《Progress in Microbiology and Immunology》 2014-01
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Comparison of titers between flocculation in vitro and neutralization in vivo of tetanus antitoxin

DUAN Li-juan;LIANG Gui-xiang;WANG Hui-ling;YANG Jun-jie;ZHANG Jin;Lanzhou institute of biological products Co.Ltd,Center for Gansu Provincial Vaccine Engineering Research;  
Objective In order to control the quality of TAT and detect titer for tetanus antitoxin quickly and accurately. Method TAT were investigated for crude plasmas and bulks from 2010 to 2013,and the correlation was statistic analyzed between neutralization potency( IU / mL) in vivo and levels of antibody titer measured by flocculation( Lf / ml) in vitro for antitoxin. Result The coefficient of correlation between flocculation titers in vitro and neutralization potency in vivo for the crude plasma and bulk is r plasma = 0.794 3( P0.001) and r bulk = 0.901 6( P 0.001),respectively. There are both significantly correlated between the two methods. Conclusion The method in vitro could be used as quality control of TAT to guide and / or replace of the method in vivo.
【CateGory Index】: S852.44
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