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《Journal of Hygiene Research》 2002-04
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Variation of gene at the apolipoprotein CⅢ locus with the changes of serum lipid profile in school-aged children

Zhu Wenli, Feng Ningping, Wang Ying Department of Nutrition and Food Hygiene, Health Science Center, Peking University,Beijing 100083, China  
The variation of gene at the apolipoprotein CⅢ locus with the changes of serum lipids in children was studied. Blood samples were collected from 308 normal children aged 7-11 year-old, including of 151 boys and 157 girls. The levels of serum lipids profile, including TC、TG、LDL-C、HDL-C、apoB、apoAⅠand Lp(a) were detected. The genome DNA was extracted from blood clot, then ApoB-XbaⅠgene polymorphism were tested by the PCR-RFLP method. The frequency of ApoCⅢ-SacⅠ heterozygote(+/-) was 48.7%, homozygote (+/+) was 7.5%, and allele (+) was 31.8% of the 308 children. The frequency of allele(+) was more than the reports in Shanghai (12%) and Guassian (6%), and closed to the Japanese (34%). The results showed a population and ethnic difference in the inheritance variation. Comparing the serum lipids levels among different genotypes, the average TG levels of homozygotes(+/+) were more than wildtype (-/+)(1.06 mmol/L vs 0.85 mmol/L,P0.05). The frequency of(+/+) genotype in hypertriglyceridemia group was more than control group (30.0% vs 6.7%,P0.05); The allele(+) could increase the TG level of 0.031mmol/L. It suggested that the variation of Apolipoprotein CⅢ-SacⅠ locus was correlated with the TG level in children.
【Fund】: 国家自然科学基金资助 (No .39770 651 )
【CateGory Index】: R153
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